Final program

German Ophthalmological Society

Welcome back to top

Dear Colleague,

during recent years there have been major advances in understanding pathogenetic factors in multifactorial complex age-related macular degeneration (AMD). The recent revolution in genetic and molecular biological studies as well as imaging and artificial intelligence has contributed significantly to our understanding of AMD. However, many open questions are still to be addressed.

We are approaching an era of new targets for therapy based on better differentiation, refined phenotyping and predictive markers of age-related macular disease. Four years after the last international Baden-Baden AMD meeting it appears timely to review emerging concepts.

We invite you again to beautiful Baden-Baden in the heart of the Blackwood Forest to the

VII. International DOG-Symposium on AMD
Age-related Macular Degeneration –
– Understanding Pathogenetic Mechanisms of the Disease –

We look forward to welcoming you in Baden-Baden.

Daniel Pauleikhoff                      Frank G. Holz

Sponsors back to top

We thank the Dr. Werner Jackstädt-Foundation for the generous support
of the Classification of Atrohy Meeting 6 - CAM-6

www.jackstaedt-stiftung.de

We thank the following companies for their generous support of
the VII. International DOG Symposium on AMD:

stiftung

Platin Sponsors:


Novartis Pharma GmbH
Roonstraße 25 • 90429 Nürnberg • Germany
www.novartis.de

Novartis Pharma GmbH  

Heidelberg Engineering GmbH
Max-Jarecki-Straße 8 • 69115 Heidelberg • Germany
www.HeidelbergEngineering.de

Heidelberg Engineering GmbH  

Bayer Vital GmbH
Geb. K56 • 51366 Leverkusen • Germany
http://www.gesundheit.bayer.de

Bayer Vital GmbH  

Gold Sponsors:


Boehringer Ingelheim International GmbH
Binger Straße 173 • 55216 Ingelheim am Rhein • Germany
www.boehringer-ingelheim.de

Boehringer Ingelheim International GmbH

 

Roche Pharma AG
Medical Affairs
Emil-Barell-Straße 1, Bau 200 - 3-W.19
79639 Grenzach-Wyhlen
Germany
www.roche.de

Roche Pharma AG

 

BergApotheke
Gildestraße 75 • 49479 Ibbenbüren • Germany
www.berg-apotheke.de

BergApotheke

 

OmniVision GmbH
Lindberghstraße 9 • 82178 Puchheim • Germany
www.omnivision.de

OmniVision GmbH

 

Silver Sponsors:


D.O.R.C. Deutschland GmbH
Schießstraße 55 • 40549 Düsseldorf • Germany
www.dorc.eu

Bayer HealthCare

 

ZEISS
Rudolf-Eber-Straße 11 • 73447 Oberkochen • Germany
www.zeiss.com

ZEISS

 

Dieter Mann GmbH
Am Glockenturm 6 • 63814 Mainaschaff • Germany
www.dieter-mann-gmbh.de

Dieter Mann GmbH

 

Eyetec GmbH
Maria-Goeppert-Straße 9 • 23562 Lübeck • Germany
www.eyetec.com

Eyetec GmbH

 

Pharm-Allergan GmbH
Westhafenplatz 6-8 • 60327 Frankfurt • Germany
www.allergan.de

Bayer HealthCare

 

Théa Pharma GmbH
Schillerstraße 3 • 10625 Berlin • Germany
www.theapharma.de

Théa Pharma GmbH

 

Bronze Sponsors:


Apellis Pharmaceuticals
6400 Westwind Way, Suite A • Crestwood, KY 40014 • USA
www.apellis.com

Apellis Pharmaceuticals

 

Bausch + Lomb.
Brunsbütteler Damm 165-173 • 13581 Berlin • Germany
www.bausch-lomb.de

Bayer HealthCare

 

General Informationback to top

Date

Friday, September 20th, 2019
08:30 - 18:00

Saturday, September 21th, 2019
08:30 - 17:30

Venue

Kongresshaus Baden-Baden
Augustaplatz 10
76530 Baden-Baden
Germany
www.kongresshaus.de

Kongresshaus Baden-Baden

Homepage

www.AMD2019.org

Scientific program

pauleikhoff Prof. Dr. Daniel Pauleikhoff
St. Franziskus Hospital
Department of Ophthalmology
Hohenzollernring 74
48145 Münster, Germany
dapauleikhoff@muenster.de


holz Prof. Dr. Frank G. Holz, FEBO, FARVO
Department of Ophthalmology
University of Bonn
Ernst-Abbe-Straße 2
53105 Bonn, Germany
Frank.Holz@ukbonn.de


Organisation

Congress Organisation Gerling GmbH
Werftstraße 23
40549 Düsseldorf, Germany
Phone: +49 211 / 592244
Fax: +49 211 / 593560
info@congresse.de
www.congresse.de

Parking facilities

Parking garage at the Kongresshaus

Information Hotline

+49 (0)2 11 / 5 37 02 69

Opening hours
congress office

Friday, September 20th, 2019
07:30 - 18:00

Saturday, September 21th, 2019
08:00 - 17:30

Official Language

English


Deadline for early registration

August 1st, 2019

Fees*

Booking until August 1st 2019 after August 1st 2019
Regular € 340 € 370
Resident*, Fellow* € 190 € 220
Student*, unemployed person* € 140 € 170

incl. VAT and excl. foreign transfer fees

* presentation of appropriate proof of status is required at the time of online-registration or may also be faxed to +49 211 / 593560; otherwise the regular fee will be charged.

Payment

by bank transfer (bank details are quoted on your confirmation) or by credit card: VISA, American Express, Mastercard, Paypal

CME credits

The symposium will be certified as further education according to the guidelines of the German Medical Association.

Important notes for participants

Reduced participation fees only apply upon appropriate proof of status.

Registration fees include lunches (Friday & Saturday), several coffee breaks and the summary of the abstracts.
If you register late or on site we cannot guarantee for lunch and/or participation in the social program.

You are encouraged to apply for the meeting either online, by mail or by fax. Cancellation for the symposium has to be made via mail or via fax (+49 (0)2 11 / 59 35 60) by September 15th, 2019 and is subject to an administration fee of € 22. No refunds can be granted for cancellations received after September 15th, 2019. Changes, errors and misprints excepted.

Hotels

See list of hotels on the registration from
(www.amd2019.org)

Presentations

L = Lectures: 10 min presentation
P = Papers: 5 min presentation
Rapid Fire Presentations 2 min presentation
Poster: Pinboard 1.60 m height x 1.30 m width

Projection

PowerPoint and Keynote Presentation on USB-Stick, DVD or CD-R



Gala dinner back to top

Friday,
September 20th 2019
at 19.30 Reception

20.00 Gala dinner
Orangerie at Brenner’s Parkhotel
Schillerstraße 4-6, Baden-Baden

Musical entertainment by the Tommy Wetzel Combo

Price per person (incl. dinner and drinks):
Regular € 65
Resident/Fellow/Student € 45


Brenner's Parkhotel


Scientific Programback to top

Friday, 20th September 2019

08:30

Opening remarks and welcome
Daniel Pauleikhoff (Münster)
Frank G. Holz (Bonn)

08:45 - 10:35

1st Session
AMD basics
Moderators:
SriniVas Sadda
(Los Angeles/USA)
Steffen Schmitz-Valkenberg (Bonn)

1 L

Alan C. Bird (London/GB)
Why the macula? – Learnings from the MacTel project

2 L

Philip J. Luthert (London/GB)
Cellular structures - computational biology of the macula

3 L

Christine A. Curcio1, D. Kar1, D.M. Dacey2, D.M.G. Anderson3, A. Kotnala3, K.L. Schey3 (1Birmingham/USA., 2Seattle/USA, 3Nashville/USA)
Molecular microarchitecture of macula in health and AMD

4 L

Robert Mullins (Iowa City/USA)
Addressing choriocapillaris degeneration in AMD:
Cause, consequences, and potential therapies

5 L

Sandra Liakopoulos (Cologne/D)
Macular Imaging - Morphology and changes in AMD and aging?

5a L

Usha Chakravarthy1, B. Reeves2, R. Evans2, C. Rogers2 (1Belfast/GB, 2Bristol/GB)
Extended follow up from the IVAN trial

5b L

Eric Souied (Paris/F)
Pathways from CNV to fibrosis

6 L

Marius Ueffing1, A. Armento1, S. Honisch1, M.A. Meester-Smoor2, C. Delcourt3, C.C.W. Klaver4, J. Monés5, L. Serrano6, C. Kiel5, A.I. den Hollander1, I. Lengyel7, T. Peto7, B. de la Cerda5, F. Pol9, P.J. Luthert8 for the EYE-RISK Consortium (1Tübingen, D; 2Nijmegen/NL, 3Bordeaux/F, 4Rotterdam/NL, 5Barcelona/E, 6Sevilla/E, 7Belfast UK, 8London, UK, 9Dublin, IRE)

Using cell lines - identify, model and validate AMD risk factors and disease drivers

7 P

Anita de Breuk1, I.E. Acar1, E. Kersten1, M.M.V.A.P. Schijvenaars1, M.A. Meester-Smoor2, C. Delcourt3, C.C.W. Klaver2, J. Monés4, D. Pauleikhoff5, R. Silva6, S. Fauser7, C.B. Hoyng1, M.J.H. Coenen1, A.I. den Hollander1, EYE-RISK Consortium (1Nijmegen/NL, 2Rotterdam/NL, 3Bordeaux/F, 4Barcelona/E, 5Münster/D, 6Coimbra/P, 7Cologne/D)
Development of a Genotyping Assay for AMD:
The EYE-RISK Consortium

8 P

Thomas J. Heesterbeek1, E.K. de Jong1, I.E. Acar1, J.M.M. Groenewoud1, B. Liefers1, C.I. Sánchez1, T. Peto2, C.B. Hoyng1, D. Pauleikhoff3, H.W. Hense3, A.I. den Hollander1 (1Nijmegen/NL, 2Belfast/GB, 3Münster/D)
Genetic Risk Score has added value over initial clinical grading stage in predicting disease progression in patients with non-advanced age-related macular degeneration – The Muenster Aging and Retina Study (MARS)

10:35 - 11:05

Coffee break in the industrial exhibition area

11:05 - 12:45

2nd Session
Genetics and risk factors of AMD
Moderators:
Carel B. Hoyng
(Nijmegen/NL)
Bernhard H.F. Weber (Regensburg/D)

9 L

Bernhard H.F. Weber (Regensburg/D)
AMD – Searching for targeted therapies

10 L

Carel B. Hoyng (Nijmegen/NL)
AMD genotype-phenotype correlation?

11 L

Magda A. Meester-Smoor, C.C.W. Klaver (Rotterdam/NL)
EyeRisk Study – risk factors for AMD phenotypes and progression?

12 L

Giovanni Staurenghi (Milan/I)
How to differentiate GA phenotypes – the CAM initiative

13 L

Frank G. Holz, S. Schmitz-Valckenberg, M. Schmid, G.S. Rubin, H. Dunbar, A. Tufail, D.P. Crabb, A. Binns, C.I. Sánchez, P. Margaron, G. Normand, M.K. Durbin, U.F.O. Luhmann, P. Zamiri, J. Cunha-Vaz, F. Asmus F, R.P. Finger, on behalf of the MACUSTAR consortium
MACUSTAR: Development and Clinical Validation of Functional, Structural, and Patient-Reported Endpoints in Intermediate Age-Related Macular Degeneration

14 L

Steffen Schmitz-Valkenberg (Bonn/D)
Challenges in phenotyping geographic atrophy

15 L

Andrew Lotery1, J R. Sutton1, S. Khandhadia1, G. Menon2, C. Bailey3, S. Sivasprasad4, Q. Mohamed5, P. Bishop6, P. Charbel Issa7, D. Steel8, T. Peto3, W. Amoaku9, R. Arora10, P. Prakash11, W. Innes12, R. Maclaren7, D. Kavanagh12 (1 Southampton/GB, 2Camberley/GB, 3Bristol/GB, 4London/GB, 5Cheltenham/GB, 6Manchester/GB, 7Oxford/GB, 8Sunderland/GB, 9Nottingham/GB, 10Salisbury/GB, 11Harlow/GB, 12Newcastle/GB)
Rare genetic variants in geographic atrophy

16 L

Sobha Sivaprasad (London/GB)
Early loss of color vision on drusen and reticular pseudodrusen

12:45 - 14:00

Lunch

14:00 - 15:30

3rd Session
Complement, inflammation and cellular energetics in AMD
Moderators:
Philip J. Luthert
(London/GB)
Marius Ueffing (Tübingen/D)

17 L

Gregory S. Hageman, C.M. Pappas, R.A. Anstadt, J.Liu, B.L. Williams, N.A. Seager, J.L. Hageman, M. Zouache, K. Curtin, B.T. Richards (Salt Lake City/USA)
Complement-directed AMD is a distinct, genotype-driven subset of the disease

18 L

Bradley D. Gelfand, J. Ambati (Charlottesville/USA)
Inflammasome in AMD

19 L

Tim U. Krohne1, L. Wang1, S. Schmidt1, J. Rossa1, P.P. Larsen1, J.H. Meyer1, W.R. Roush2, E. Latz1,2, F.G. Holz1 (1Bonn/D, 2Boston/USA)
NLRP3 inflammasome as a therapeutic target in AMD

20 L

Glen Jeffery (London/GB)
Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near infrared light

21 L

Imre Lengyel (Belfast/IRL)
Is mineralization a major factor in drusen pathogenesis?

22 P

Martin Zinkernagel, D. Zysset, I. Keller, L. Berger, B. Yilmaz, S. Wolf (Bern/CH)
Associations of the intestinal microbiome with AMD

23 P

Ilhan Erkin Acar1, L. Lores de Motta1, M.A. Meester2, S. Ajana3, D. Pauleikhoff4, S. Fauser5, C.B. Hoyng1, C. Delcourt3, C.C.W. Klaver2, T.E. Galesloot1, A.I. den Hollander1 (1Nijmegen/NL, 2Rotterdam/NL, 3Bordeaux/F, 4Münster/D, 5Cologne/D)
Metabolomics identifies lipoprotein subclasses and dietary metabolites that are associated with AMD: The EYE-RISK Consortium

24 P

Yara Lechanteur1, T. Heesterbeek1, L. Lorés-Motta1, T. Schick2, M. Daha3, L. Altay2, S. Liakopoulos2, D. Smailhodzic1, A. den Hollander1, C. Hoyng1, E. de Jong1, B. Klevering1 (1Nijmegen/NL, 2Cologne/D, 3Leiden/NL)
Complement activation levels are related to disease stage in AMD

25 P

Laura Lorés de Motta1, V. Cipriani2, F. He3, D. Fathalla4, S. McHarg3, N. Bayatti3, I.E. Acar1, C.C.B. Hoyng1, S. Fauser5,6, A. Moore2,7, J.R.W. Yates2,8, P. Morgan4, E.K. de Jong1, A.I. den Hollander1, P.N. Bishop3, S.J. Clark3 (1Nijmegen/NL, 2London/GB 3Manchester/GB, 4Cardiff/GB, 5Cologne/D, 6Basel/CH, 7San Francisco/USA, 8Cambridge/GB,)
Factor H-Related Protein 4 (FHR-4) drives complement dysregulation in AMD

26 P

Anja Schlecht1, P. Wieghofer1,2, P. Zhang1, S. Bonvea1, M. Gruber1, R. Sankowski1, G. Schlunck1, H. Agostini1, M. Prinz1, C. Lange1 (1Freiburg i.Br./D, 2Leipzig/D)
Identification of myeloid cell populations at sites of laser-induced choroidal neovascularization by single-cell profiling

27 P

Alexa Klettner, K. Winkelmann, A. Brinkmann, T. Käckenmeister, J. Roider (Kiel/D)
Effect of long-term inflammation on viability and function of RPE cells

15:30 - 16:15

Coffee break in the industrial exhibition area

16:15 - 17:40

4th Session
Neurobiology of the outer retina I
Moderators:
Deborah A. Ferrington
(Minneapolis/USA)
John G. Flannery (Berkley/USA)

28 L

Thomas Langmann, A. Wolf (Cologne/D)
Microglia as important part of the retina: Its role in AMD

29 P

Clemens Lange1, A. Schlecht1, S. Boneva1, J. Wolf1, P. Zhang1, G. Prinz1, R. Horres2, F. Bucher1, C. Auw-Haedrich1, L. Hansen1, A. Stahl1,3, I. Hilgendorf1, H. Agostini1, P. Wieghofer4, G. Schlunck1 (1Freiburg i.Br./D, 2Frankfurt/D, 3Greifswald/D, 4Leipzig/D)
Transcriptomic characterization of human choroidal neovascular membranes
identifies calprotectin as a novel biomarker for patients with AMD

30 L

Rajendra S. Apte (St. Louis/USA)
Animal model for AMD interfering lipid trafficking

31 P

Christian Grimm1, F. Storti1, T. Hornemann1, A. den Hollander2, C. Maugeais3
(1Schlieren/CH, 2Nijmegen/NL, 3Basel/CH)
Impaired function of the lipid transporters ABCA1 and ABCG1 in
the RPE leads to an AMD-like phenotype in mice

32 L

Nicolas Bazan1,2 (1New Orleans/USA, 2Stockholm/S)
Elovanoids are novel photoreceptor survival signals relevant to AMD

33 L

Clare Futter, M. Hall, H. Cardosa, M.C. Seabra (London/GB)
Lysosome dysfunction in the RPE and its role in early AMD

34 L

Gerard A. Lutty, S. Ogura, R. Baldeosingh, D.S. McLeod, M.M. Edwards, I.A. Bhutto (Baltimore/USA)
Mast cell involvement in geographic atrophy

17:40 - 18:00

Lecture in memory of Gerhard Zinser:

Moderators:
Frank G. Holz
Daniel Pauleikhoff

35

Josef F. Bille (Heidelberg/D)
Past, present and new horizons in imaging analysis - The heritage of Gerhard Zinser

19:30

Reception at “Brenner’s Park Hotel”

20:00

Gala dinner


Saturday, 21th September 2019

08:30 - 09:55

5th Session
Neurobiology of the outer retina II
Moderators:
Thomas Langmann
(Cologne/D)
Anneke den Hollander (Nijmegen/NL)

36 L

Janet Sparrow (New York/USA)
Is lipofuscin a relevant factor in the pathogenesis of AMD?

37 P

Thomas Ach1, K. Bermond1, J. A. Gambril2, C. Wobbe1, A. Berlin1,
R. Heintzmann2,3, K.R. Sloan3, C.A. Curcio3 (1Würzburg/D, 2Jena/D, 3Birmingham/USA)
Cellular and subcellular changes in the RPE:
from normal aging to early signs of AMD

38 L

Deborah A. Ferrington (Minneapolis/USA)
A bioenergetic crisis in the RPE drives AMD pathology

39 P

Natalie Wagner1, N. Wagner1, M. Gammel1, A. Greulich1, S. Reinehr1, J. Hurst2, H.B. Dick1, S. Schnichels2 (1Bochum/D, 2Tübingen/D)
Novel porcine organ culture model for AMD research

40 L

Anneke den Hollander (Nijmegen/NL)
Understanding disease mechanisms in AMD:
From serum biomarkers to an organ-on-a-chip model for AMD

41 L

John G. Flannery1, M.H. Berry1,2, A. Holt1, A. Salari1, J. Veit1, M. Visel1, J. Levitz1,3, K. Aghi1, B. Gaub1,4, B. Sivyer2, E. Isacoff1, (1California/USA, 2Oregon/USA, 3New York/USA, 4Zürich/CH)
Restoration of high-sensitivity and adapting vision with a cone opsin

42 L

Volker Busskamp (Bonn/D)
Forward programming of human photoreceptors

43 P

Giuliana Gagliardi1, D.M. Feitosa-Afonsso1,2, Y.B. Arik2, J. Heesterbeek1, C.B. Hoyng1, A.D. van der Meer2, A.I. den Hollander1 (1Nijmegen/NL, 2Enschede/NL)
Using human-induced pluripotent stem cells for modelling the blood-retinal-barrier on-a-chip

09:55 - 10:45

6th Session
Posters / Rapid Fire Presentations
Moderators:
Frank G. Holz
(Bonn)
Daniel Pauleikhoff (Münster)

P 01

Susette Lauwen, D.J. Lefeber, E.K. de Jong, A.I. den Hollander (Nijmegen/NL)
B3GLCT-catalyzed O-fucose glucosylation is not required for secretion of TSP1 and CTGF from retinal pigment epithelial cells

P 02

Ana Sofia Falcão1, M.H. Cardoso1, M. Hall2, C. Escrevente1, P. Antas1, M. Chaves-Ferreira1, S. Tenreiro1, C.E. Futter2, M.C. Seabra1 (1Lisbon/P; 2London/GB)
Dissecting the role of lysosome dysfunction in AMD

P 03

Angela Armento, S. Honisch, V. Panagiotakopoulou, I. Sonntag, A. Jacob, M. Deleidi, M. Ueffing (Tübingen/D)
Complement factor H (CFH) loss alters energy metabolism and hinders the antioxidant capacity of RPE cells

P 04

Corinne Gonzales (Toulouse/F)
Clinical, morphology-structural, biological biomarkers for AMD and its atrophy and neovascular complications

P 05

Eric Thee1, M. Meester1, D. Luttikhuizen1, D. Rizoupolos1, C. Klaver1,2 (1Rotterdam/NL, 2Nijmegen/NL)
Performance of classification systems for AMD

P 06

Damian Jaggi, Y. Solberg, C. Dysli, S. Wolf, M. Zinkernagel (Bern/CH)
Correlations in mulitmodal macular pigment measurements and fluorescence lifetime imaging opthalmoscopy in AMD

P 07

Gereon Hüttmann1, P. Koch1, H. Sudkamp1, M. Moltmann1, D. Theisen-Kunde1, C. Pfäffle1, D. Hillmann1, C. von der Burchard2, J. Tode2, C. Ehlken2, T. Kepp1, H. Handels1, R. Birngruber1, J. Roider2 (1Lübeck/D, 2Kiel/D)
Full-field OCT for imaging AMD progression

P 08

Alaadin Abdin, S. Suffo, A. Langenbucher, B. Seitz (Homburg/D)
Intravitreal ranibizumab versus aflibercept following treat and extend protocol for neovascular AMD (2 years follow up)

P 09

Martin Ziegler1, M. Book1, K. Rothaus1, G. Spital1, A. Lommatzsch1,2, D. Pauleikhoff1,2 (1Münster/D, 2Essen/D)
Multimodal analysis and phenotypical characterisation of CNV-transformation in exudative AMD after longterm anti-VEGF- therapy

P 10

Marius Book1, M. Ziegler1, K. Rothaus1, M.L. Farecki1, G. Spital1,
A. Lommatzsch1,2, D. Pauleikhoff1,2 (1Münster/D, 2Essen/D)
Analysis of the vascular properties of the choroidal neovascularization (CNV) undergoing fibrovascular transformation in neovascular AMD using optical coherence tomography angiography (OCTA)

P 11

Matthias Gutfleisch, O. Ester, K. Rothaus, P. Mussinghoff, G. Spital, A. Lommatzsch, H. Kurzhals, D. Pauleikhoff (Münster/D)
Text mining based data collection from unstructured, electronic patient data

P 12

Jan Tode1, E. Richert1, C.v d. Burchard1, R. Brinkmann2, R. Lucius1, A. Klettner1, J. Roider1 (1Kiel/D, 2Lübeck/D)
Translational evaluation of selective retina therapy and thermal stimulation of the retina as therapeutic means for AMD

P 13

Andrii Serhiienko1, O. Pekaryk2, N.Dziuba3 (1Vinnitsa/UA, 2Winnipeg/CDN, 3Kyiv/UA)
Low-energy light treatment of wet AMD after completion of standard anti-VEGF therapy

P 15

Benedikt Schworm, J. Siedlecki, F. Hagenau, K. Kortüm, N. Luft, S. Priglinger (Munich/D)
Response of secondary choroidal neovascularization in chronic central serous chorioretinopathy to an extended upload of anti-VEGF agents

P 16

Satpal Ahuja (Lund/S)
Glycan analyses of rd1 mouse retinal proteins (a model of retinitis pigmentosa) indicates a need for therapy to hyper-glycosylate mutated synaptic proteins and to improve outcome of current gene therapies

P 17

Céline Koster1, F. Barone2, A. Maminishkis3, M. Jae Song2, R. Quinn2, C. Lewallen4, J.C. van Meurs5,6, F.D. Verbraak7, T. H. Smit8, J. B. ten Brink1, A.L.M.A ten Asbroek1, C.J. Boon7,9, K. Bharti2, A.A. Bergen1,7,10 (1Department of Clinical Genetics, Amsterdam University Medical Centers (AUMC), University of Amsterdam (UvA), location Meibergdreef, Amsterdam/NL, 2 Unit on Ocular Stem Cell and Translational Research, National Eye Institute (NEI), Bethesda/USA, 3 Section on Epithelial and Retinal Physiology and Disease, NEI, Bethesda/USA, 4 Georgia Institute of Technology, G.W. Woodruff School of Mechanical Engineering, Atlanta/USA, 5 Rotterdam Eye Hospital, Rotterdam/NL, 6 Department of Ophthalmology, Erasmus Medical Center, Rotterdam/NL; 7 Department of Ophthalmology, AMC, UvA, Amsterdam/NL; 8 Anatomy, Embryology and Physiology, Amsterdam Movement Sciences, AUMC, UvA, Amsterdam/NL, 9 Department of Ophthalmology, Leiden University Medical Center, Leiden/NL, 10 The Netherlands Institute for Neuroscience (NIN-KNAW), Amsterdam/NL)
Towards experimental stem cell-based therapy for Age-related Macular Degeneration - Transplantation of patient derived-tissues in the rat subretinal space

10:45 - 11:15

Coffee break at the posters in the industrial exhibition area

11:15 - 13:00

7th Session
Phenotyping AMD: Advances in Imaging
Moderators:
Richard F. Spaide
(New York/USA)
Giovanni Staurenghi (Milan/I)

43a L

Richard F. Spaide (New York/USA)
Imaging the Choriocapillaris with OCT-angiography

44 L

SriniVas Sadda (Los Angeles/USA)
Choriocapillaris status as a risk factor in AMD

45 L

Philip J. Rosenfeld (Miami/USA)
Choriocapillaris imaging using SS-OCT angiography in AMD

46 P

Martin Hammer, R. Schultz, D. Meller (Jena/D)
Clinicopathologic comparison of fluorescence lifetimes and spectral characteristics in AMD

47 L

Sebastian Wolf, C. Dysli, M.S. Zinkernagel (Bern/CH)
Fluorescence lifetimes in AMD

48 P

Lydia Sauer, A.S. Vitale, N.K. Modersitzki, E.D. Hansen, C. B. Komanski, P.S. Bernstein (Salt Lake City/USA)
Imaging of AMD with FLIO

49 L

Adam Dubis (London/GB)
Adaptive optics photoreceptor imaging, function and survival in AMD

50 P

Thomas Theelen, P.P.A. Dhooge, T.W.F. Mulders, C.B. Hoyng (Nijmegen/NL)
In vivo photoreceptor imaging by non-adaptive optics confocal scanning laser ophthalmoscopy

51 P

R. Theodore Smith, K.B. Freund (New York City/USA)
Quantitative fundus autofluorescence (qAF) of GA secondary to AMD

52 L

Daniel F. Martin (Cleveland/USA)
Why did GA trials fail - how to overcome obstacles?

53 P

Victor Chong (Ingelheim/D)
Neuroprotection as a therapeutic option for GA

13:15 - 14:15

Lunch

14:15 - 17:00

8th Session
Dissecting AMD: Novel approaches
Moderators:
Frank G. Holz
(Bonn/D)
Daniel Pauleikhoff (Münster/D)

54 L

Adnan Tufail (London/GB)
Application of deep learning-based automated segmentation in OCT on AMD

55 L

Aaron Lee (Washington/USA)
Deep learning applications with OCT in AMD

56 L

Karl Csaky1, M. Oulette2, C. Clark2 (1Dallas/USA, 2Plano/USA)
Developing human based intuitive deep learning
algorithms for analyzing intermediate AMD OCT-Images

57 L

Glenn J. Jaffe (Durham/GB)
Challenges of clinical relevant phenotyping of exudative AMD

59 L

Giuseppe Querques1,2, R. Sacconi1, V. Capuano2, A. Carnevali1,3, D. Colantuono2, M. Battista1, E. Borrelli1, A. Miere2, M.Parravano4, E. Costanzo4, L. Querques1, E.H. Souied2, F. Bandello1 (1Milan/I, 2Creteil/F, 3Catanzaro/I, 4Rome/I)
„Quiescent“ CNV in AMD – characteristics and consequences

60 P

Maximilian Pfau1, L. von der Emde1, C. Dysli2, P.T. Möller1, S. Thiele1, M. Lindner3, M. Schmid1, S. Schmitz-Valckenberg1, F.G. Holz1, M. Fleckenstein1 (1Bonn/D, 2Bern/CH, 3Oxford/GB)
Type-1 choroidal neovascularization reduces the progression of atrophy in eyes with AMD

61 L

David Sarraf (Los Angeles/USA)
Mechanisms and pathways of PED development in neovascular AMD

62 L

K. Bailey Freund (New York City/USA)
Type 3 CNV – a specific phenotype?

63 L

John Marshall (London/GB)
Can a nanosecond beam modulated laser improve transport mechanisms and delaying progression towards late AMD?

64 L

Robyn Guymer - LEAD study team (Melbourne/AUS)
Natural history and modulation of drusen by laser:
The LEAD randomized controlled trial of sub-threshold nanosecond laser intervention in AMD

66 L

Daniel Pauleikhoff1,2, Marie-Luise Farecki1, Henrik Faatz1, K. Rothaus1, G. Spital1, A. Lommatzsch1,2, (1Münster/D, 2Essen/D)
Mathematical characterization of CNV before and under anti-VEGF-therapy

68 P

Heinrich Gerding (Olten/CH)
10 years anti-VEGF treatment outcomes on neovascular AMD

69 L

Ricarda G. Schumann, V. Deiters, S.R. Günther, D. Vogt, J. Siedlecki, S.G. Priglinger (Munich/D)
Long-term visual acuity outcomes and anatomic results from anti-VEGF-therapy in patients with neovascular AMD in a real-life setting

70 P

Jakob Siedlecki, C. Fischer, B. Schworm, T.C. Kreutzer, K. Kortüm, R. Schumann, A. Wolf, S.G. Priglinger (Munich/D)
Long-term incidence of macular atrophy and clinical outcomes in neovascular AMD managed to sub-retinal fluid only

17:00

Adjourn
Frank G. Holz
Daniel Pauleikhoff


Authors back to top

Alaadin Abdin
Universitäts-Augenklinik
Kirrberger Straße 100, Geb. 22
66424 Homburg / Saar
Germany

Ilhan Erkin Acar
Radboud University Medical
Centre
Philips van Leydenlaan 15
6525 EX Nijmegen
The Netherlands

Thomas Ach
Universitäts-Augenklinik
Josef-Schneider-Straße 2
97080 Würzburg
Germany

Dr. Satpal Ahuja
Lund University
Institut of Clinical Sciences
Department of Ophthalmology
Klinikgatan 26, BMC, B-11
221 84 Lund
Sweden

Rajendra S. Apte
Washington University
St. Louis School of Medicine
660 South Euclid Avenue
MO 63110 St. Louis
USA

Angela Armento
Universitäts-Augenklinik
Elfriede-Aulhorn-Straße 7
72076 Tübingen
Germany

Nicolas G. Bazan
LSU Health New Orleans
Neuroscience Center of
Excellence
2020 Gravier Street, Suite D
LA 70119 New Orleans
USA

Josef F. Bille
Kirchhoff-Institut für Physik
Im Neuenheimer Feld 227
69120 Heidelberg
Germany

Alan C. Bird
Moorfields Eye Hospital
162 City Road
ECIV 2PD London
UK

Giuliana Gagliardi
Radboud University
Medical Centre
Department of Ophthalmology
Philips van Leydenlaan 15
6525 EX Nijmegen
The Netherlands

Bradley D. Gelfand
University of Virginia
School of Engineering &
Applied Sciences
415 Lane Rd, MR-5
VA 22908 Charlottesville
USA

Heinrich Gerding
Klinik Pallas
Abteilung für Retinologie
Louis-Giroud-Strasse 20
4600 Olten
Switzerland

Corinne Gonzales
Futurophtha Private Practice
27 Boulevard des MInimes
31200 Toulouse
France

Christian Grimm
UniversitätsSpital Zürich
Augenklinik
Labor für Zellbiologie der
Netzhaut
Wagistrasse 14
8952 Schlieren
Switzerland

Matthias Gutfleisch
Augenzentrum am
St. Franziskus-Hospital
Hohenzollernring 74
48145 Münster
Germany

Robyn H. Guymer
University of Melbourne
Centre for Eye Research
Australia
Level 7, 32 Gisborne Street
VIC 3002 East Melbourne
Australia

Yara Lechanteur
Radboud University Medical
Centre
Department of Ophthalmology
Philips van Leydenlaan 15
6525 EX Nijmegen
The Netherlands

Aaron Lee
University of Washington
Eye Institute at Harborview
908 Jefferson Street
WA 98104 Seattle
USA

Imre Lengyel
Queen‘s University Belfast
School of Medicine, Dentistry
and Biomedical Sciences
97 Lisburn Road
BT9 7BL Belfast
UK

Sandra Liakopoulos
Universitäts-Augenklinik
Kerpener Straße 62
50937 Köln
Germany

Laura Lorés de Motta
Radboud University
Medical Centre
Department of Ophthalmology
Philips van Leydenlaan 15
6525 EX Nijmegen
The Netherlands

Andrew J. Lotery
University of Southampton
Southampton General Hospital
Tremona Road
SO16 6YD Southampton
UK

Philip J. Luthert
University College London
Institute of Ophthalmology
11-43 Bath Street
EC1V 9EL London
UK

Steffen Schmitz-Valckenberg
Universitäts-Augenklinik
Ernst-Abbe-Straße 2
53127 Bonn
Germany

Ricarda G. Schumann
Augenklinik der LMU
Mathildenstraße 8
80336 München
Germany

Benedikt Schworm
Augenklinik der LMU
Mathildenstraße 8
80336 München
Germany

Andrii Serhiienko
Medical Centre
Pirogova Street 47A
21000 Vinnitsa
Ukraine

Jakob Siedlecki
Augenklinik der LMU
Mathildenstraße 8
80336 München
Germany

Sobha Sivaprasad
Moorfields Eye Hospital
162 City Road
ECIV 2PD London
UK

R. Thedore Smith
NYU School of Medicine
462 First Avenue
NY 10016 New York
USA

Eric H. Souied
Universite de Paris XII
Clinique Ophthalmique
40 Avenue Verdun
94000 Créteil
France

Marius Book
Augenzentrum am
St. Franziskus-Hospital
Hohenzollernring 74
48145 Münster
Germany

Volker Busskamp
Universitäts-Augenklinik
Ernst-Abbe-Straße 2
53127 Bonn
Germany

Usha Chakravarthy
Queens University of Belfast
Centre for Experimental
Medicine
Grosvenor Road
BT12 6BA Belfast
UK

Victor Chong
Boehringer Ingelheim
Pharma GmbH
Binger Straße 173
55216 Ingelheim
Germany

Karl Csaky
Retina Foundation of the
Southwest
9600 N Central Expressway,
Suite 200
TX 75231 Dallas
USA

Christine A. Curcio
University of Alabama
School of Medicine
Department of Ophthalmology
1670 University Blvd.
AL 35233 Birmingham
USA

Anita de Breuk
Radboud University Medical
Centre
Philips van Leydenlaan 15
6525 EX Nijmegen
The Netherlands

Gregory S. Hageman
University of Utah
John A. Moran Eye Center
65 N. Mario Capecchi Drive
UT 84132 Salt Lake City
USA

Martin Hammer
Universitäts-Augenklinik
Am Klinikum 1
07747 Jena
Germany

Thomas J. Heesterbeek
Radboud University
Medical Centre
Philips van Leydenlaan 15
6525 EX Nijmegen
The Netherlands

Frank G. Holz
Universitäts-Augenklinik
Ernst-Abbe-Straße 2
53127 Bonn
Germany

Carel B. Hoyng
Radboud University
Medical Centre
Department of Ophthalmology
Philips van Leydenlaan 15
6525 EX Nijmegen
The Netherlands

Gereon Hüttmann
Institute of Biomedical Optics
Peter-Monnik-Weg 4
23562 Lübeck
Germany

Glenn J. Jaffe
Duke University Medical Center
Duke Eye Center
2351 Erwin Road
NC 27710 Durham
USA

Damian Jaggi
Universtitätsklinik für
Augenheilkunde Bern
Freiburgstrasse 18
3010 Bern
Switzerland

Jeffrey K. Luttrull
Jeffrey K. Luttrull, M.D. -
A professional corporation
3160 Telegraph Rd., Suite 230
CA 93003 Ventura
USA

Gerard A. Lutty
Johns Hopkins Hospital
Wilmer Eye Institute
400 North Broadway
MD 21287 Baltimore
USA

John Marshall
University College London
Institute of Ophthalmology
11-43 Bath Street
EC1V 9EL London
UK

Daniel F. Martin
Cleveland Clinic
Cole Eye Institute
9500 Euclid Avenue
OH 44195 Cleveland
USA

Magda A. Meester
Erasmus Medical Center
Dept. of Ophthalmology
Dr. Molewaterplein 40
3015 GD Rotterdam
The Netherlands

Robert F. Mullins
University of Iowa
Department of Ophthalmology
Stephen A. Wynn Institute for
Vision Research
375 Newton Road
IA 52242 Iowa City
USA

Daniel Pauleikhoff
Augenzentrum am
St. Franziskus-Hospital
Hohenzollernring 74
48145 Münster
Germany

Richard F. Spaide
Vitreous Retina Macula
Consultants of New York
460 Park Avenue, 5th Floor
NY 10022 New York
USA

Janet R. Sparrow
Columbia University
Department of Ophthalmology
635 West 165th Street
NY 10032 New York
USA

Giovanni Staurenghi
University of Milan - Sacco
Hospital
Dept. of Biomedical and
Clinical Science
“Luigi Sacco“ - Eye Clinic“
via G.B. Grassi, 74
20157 Milano
Italy

Eric Thee
Erasmus University Medical
Center
Doctor Molewaterplein 40
3015 GD Rotterdam
The Netherlands

Thomas Theelen
Radboud University
Medical Centre
Department of Ophthalmology
Philips van Leydenlaan 15
6525 EX Nijmegen
The Netherlands

Jan Tode
Universitätsklinikum
Schleswig-Holstein
Campus Kiel
Klinik für Augenheilkunde
Arnold-Heller-Straße 3
24105 Kiel
Germany

Adnan Tufail
Moorfields Eye Hospital
162 City Road
EC1V 2PD London
UK
Anneke den Hollander
Radboud University
Medical Centre
Department of
Ophthalmology
Philips van Leydenlaan 15
6525 EX Nijmegen
The Netherlands

Adam Dubis
University College London
Institute of Ophthalmology
11-43 Bath Street
EC1V 9EL London
UK

Ana Sofia Falcão
Chronic Diseases Research
Center Universidade Nova de
Lisboa
Campo dos Mártires da Pátria,
130 1169-056 Lisboa
Portugal

Deborah A. Ferrington
University of Minnesota
Dept. of Ophthalmology and
Visual Neuroscienc
381 Lions Research Bldg
2001 6th St SE
MN 55455 Minneapolis
USA

John G. Flannery
University of California
The Flannery Lab
112 Barker Hall
CA 94720 Berkeley
USA

K. Bailey Freund
Vitreous Retina Macula
Consultants of New York
460 Park Avenue, 5th Floor
NY 10022 New York
USA

Clare Futter
University College London
Institute of Ophthalmology
11-43 Bath Street
EC1V 9EL London
UK

Glen Jeffery
University College London
Institute of Ophthalmology
11-43 Bath Street
EC1V 9EL London
UK

Stephanie C. Joachim
Universitäts-Augenklinik
In der Schornau 23-25
44892 Bochum
Germany

Alexa Klettner
Universitätsklinikum
Schleswig-Holstein
Campus Kiel
Klinik für Augenheilkunde
Arnold-Heller-Straße 3
24105 Kiel
Germany

Tim U. Krohne
Universitäts-Augenklinik
Ernst-Abbe-Straße 2
53127 Bonn
Germany

Clemens Lange
Universitäts-Augenklinik
Killianstraße 5
79106 Freiburg i. Breisgau
Germany

Thomas Langmann
Universitätsklinikum Köln
Zentrum für Augenheilkunde
Experimentelle Immunologie
des Auges
Joseph-Stelzmann-Straße 9
50931 Köln
Germany

Susette Lauwen
Radboud University
Medical Centre
Philips van Leydenlaan 15
6525 EX Nijmegen
The Netherlands

Maximilian Pfau
Universitäts-Augenklinik
Ernst-Abbe-Straße 2
53127 Bonn
Germany

Giuseppe Querques
University Vita-Salute
IRCCS Ospedale San Raffaele
Clinica Oculistica
Via Olgettina, 60
20132 Milano
Italy

Philip J. Rosenfeld
Bascom Palmer Eye Institute
University of Miami
Miller School of Medicine
900 NW 17th Street
FL 33136 Miami
USA

SriniVas Sadda
University of California -
Los Angeles (UCLA)
David Geffen School of Medicine
Office of the President & CSO
PO Box 86228
CA 90086 Los Angeles
USA

David Sarraf
Jules Stein Eye Institute (UCLA)
Dept. of Ophthalmology
100 Stein Plaza
CA 90402 Los Angeles
USA

Lydia Sauer
Universitäts-Augenklinik
Am Klinikum 1
07747 Jena
Germany

Anja Schlecht
Universitäts-Augenklinik
Killianstraße 5
79106 Freiburg i. Breisgau
Germany

Marius Ueffing
Universitätsklinikum
Tübingen
Forschungsinstitut für
Augenheilkunde
Elfriede-Aulhorn-Straße 7
72076 Tübingen
Germany

Bernhard H. F. Weber
Universitätsklinikum
Institut für Humangenetik
Franz-Josef-Strauß-Allee 11
93053 Regensburg
Germany

Sebastian Wolf
Universitäts-Augenklinik
Inselspital
Freiburgstrasse 8
3010 Bern
Schweiz

Martin Ziegler
Augenzentrum am
St. Franziskus-Hospital
Hohenzollernring 74
48145 Münster
Germany

Martin S. Zinkernagel
Universitäts-Augenklinik
Inselspital
Freiburgstrasse 8
3010 Bern
Switzerland


Exhibitorsback to top

Aprofol AG
Brülisauerstrasse 18
9050 Appenzell
Switzerland
www.aprofol.com

Centervue S.p.A.
Via San Marco, 9H
35129 Padova
Italy
www.centervue.com

Eyetec GmbH
Maria-Goeppert-Straße 9
23562 Lübeck
Germany
www.eyetec.com

Dieter Mann GmbH
Am Glockenturm 6
63814 Mainaschaff
Germany
www.dieter-mann-gmbh.de

NIDEK Co. Ltd. / OCULUS Optikgeräte GmbH
Münchholzhäuser Straße 29
35582 Wetzlar
Germany
www.oculus.de

Pharm-Allergan GmbH
Westhafenplatz 6-8
60327 Frankfurt
Germany
www.allergan.de

Théa Pharma GmbH
Schillerstraße 3
10625 Berlin
Germany
www.theapharma.de
Bayer Vital GmbH
Geb. K56
51366 Leverkusen
Germany
http://www.gesundheit.bayer.de

D.O.R.C. Deutschland GmbH
Schießstraße 55
40549 Düsseldorf
Germany
www.dorc.eu

Heidelberg Engineering GmbH
Max-Jarecki-Straße 8
69115 Heidelberg
Germany
www.HeidelbergEngineering.de

Novartis Pharma GmbH
Roonstraße 25
90429 Nürnberg
Germany
www.novartis.de

OmniVision GmbH
Lindberghstraße 9
82178 Puchheim
Germany
www.omnivision.de

Roche Pharma AG - Medical Affairs
Emil-Barell-Straße 1, Bau 200 - 3-W.19
79639 Grenzach-Wyhlen
Germany
www.roche.de

ZEISS
Rudolf-Eber-Straße 11
73447 Oberkochen
Germany
www.zeiss.com

Travel back to top

By plane:
International airports
Frankfurt 170 km / Stuttgart 100 km / Basel/Mulhouse 160 km / Zürich 300 km / Strassburg 60 km – frequent train connections for all airports via Deutsche Bahn

Regional airport Karlsruhe / Baden-Baden (Baden-Airpark)
at a distance of 15 km with regular flights e.g. from Hamburg, Barcelona, Belgrad, Budapest, London (Stansted), Porto and Rom (Ciampino) to Baden-Baden. Flight connections from various destinations non-stop by Eurowings, Ryanair, Turkish Airlines, Wizz Air and many others.
Detailed information: www.baden-airpark.de/en/


By train:
The train station Baden-Baden is a stop for ICE/EC/ IC/IR trains as well as all other regional trains. Main lines Basel / Hamburg, Basel / Rheinland, Basel / Berlin and Paris / Wien via Stuttgart and München. From the train station Baden-Baden Oos and all other bus stops you can reach the city centre and the surroundings comfortable and fast by bus. Strassburg (France) can be reached in about one hour. To get to Heidelberg, Freiburg, Stuttgart or Basel (Switzerland) it takes about 1,5 hours by train.

By car:
Autobahn A5 Frankfurt-Basel Exit Baden-Baden / Direction Centrum/Congress
B500 Frankreich-Schwarzwald-Schweiz Baden-Baden / Direction Centrum/ Congress


Navigation settings
Augustaplatz 10,
76530 Baden-Baden
Germany

Parking
Kongresshaus underground car park
at the Kongresshaus
Augustaplatz 10, 76530 Baden-Baden